Peyronie’s Disease Treatment

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Peyronie’s Disease Breakthrough

ExoSurge® is our clinically-proven medical device that utilizes injected unique gases to greatly enhance the efficacy of intralesional injections of long-established Peyronie’s disease medications. These medicine combinations, when reinforced by our gas injections, eradicate permanently the penile plaques and fibrosis associated with a Peyronie’s Disease diagnosis.

At our flagship facility in Atlanta, Georgia, we have successfully treated over 1,000 patients with no adverse side effects other than moderate swelling and occasional bruising.

Using baseline and follow-up duplex Doppler sonography image comparisons, our soon-to-be-published retrospective clinical study of 75 patients demonstrated a 79% decrease in the plaques and fibrosis responsible for Peyronie’s disease’s adverse effects. Included in these measurements were patients with thick calcified plaque.

No individuals were excluded on the basis of any pre-existing health condition or their Peyronie’s diagnosis.

Breakthrough: Understanding Peyronie’s Disease

Before we could develop any cure for Peyronie’s disease, we knew we had to establish a thorough understanding of its underlying causes. This sounds more easier than it actually was. Have you ever Googled what causes “Peyronie’s disease”? There are numerous ideas, but none can explain every case. It took nearly a decade to build an appropriate working model for the aetiologia of Peyronie’s disease, and another decade to demonstrate that these assumptions were valid by the efficacy of treatment and the conservative elimination of Peyronie’s plaques, fibrosis, and scar tissue.

While we are unable to reveal all of these details at this time, we can dispel a few beliefs we’ve identified as false.

Peyronie’s Myth Number 1: “Peyronie’s disease resolves on its own in approximately 13% of cases”

This myth appears to originate from a commonly cited 2002 study1. That study also plays a role in urology failing to offer care during the initial “acute” phase of the disease.

We discovered six different Peyronie’s Accelerators (health paradigms that induce a long-standing benign case to become active). Through patient interviews, we discovered a number of instances in which a patient reported sustaining a traumatic penile injury in the past, which was followed by a noteworthy change in erection shape that afterwards faded. Subsequently, these normally healthy patients developed spontaneous symptoms later in life.

This outcome is the result of an important discovery that we call what Peyronie’s Accelerators. We have identified six different Peyronie’s Accelerators (health paradigms that induce a long-standing benign case to become active). If multiple accelerators occur about at the same time, Peyronie’s disease symptoms progress rapidly. Some of them are associated with aging, although they can occur at any moment to any patient.

We discovered significant variations in the plaque structures beneath the initial layers when we treated these patients, indicating that the initial trauma was still present but that their bodies were able to fight off the symptoms until one or more of the Peyronie’s accelerators hampered that ongoing ability.

We also discovered that a Peyronie’s diagnosis is comprised of ten distinct plaque structures. For each, a slightly different approach is required for successful removal.

A large part of this technology’s success can be attributed to our personalized diagnosis of each patient and adaptation of therapies to deficits and plaque deposits. 

[1]  Kadioglu A, Tefekli A, Erol B, et al. A retrospective review of 307 men with Peyronie’s disease. J Urol 2002; 168: 1075–1079.

Inquire about Peyronie’s Treatments

Peyronie’s Myth Number 2: “Small plaques, minimal penile curvature, no pain, and satisfactory sexual function do not necessitate treatment”

We have discovered Peyronie’s is a progressive condition. The fibrosis that occurs following severe or mild injury does not “go away”. Rather, the body can often keep negative consequences in check as long as the patient is without any Peyronie’s accelerators.

Among the ten unique plaque design aspects we discovered treating Peyronie’s were those we attributed to the body sending additional fibrotic material to the previously injured area in an effort to heal the condition.

It gets worse. The masses get bigger. And when one or more of the accelerators kick in, it becomes a nightmare diagnosis.

Peyronie’s FACT: “There has never been, and will never be, a simple and quick cure for Peyronie’s Disease.”

Finally, understand there’s not and never will be a quick and easy solution to cure Peyronie’s Disease.

Peyronie’s symptoms have been documented in medical journals since the 1400s. It was named after the personal physician to Louis XV in France in 1743, who was the first to describe it clinically and added his name to it. Beyond treating some of its symptoms, there has never been a curative Peyronie’s treatment. There’s not even agreement on what is causing it.

How many diseases have been identified that long with such little success with treatment? To understand the complexities of this disease, you must respect those failures.

We’ve spent twenty years focused on this disease. It took ten years just to develop a working theory model on the etiology alone. We discovered six Peyronie’s Accelerators that cause a long benign case to go south, as well as ten distinct plaque structures that must be identified in order to successfully remove them. Then there’s the exact plaque size, location, and density, which are determined by high-level sonograms. That doesn’t even take into account the fact that all of the masses are attached just above the penile neuro network, making surgical removal of the plaque impossible.

Peyronie’s: Don’t get scammed

Please don’t fall for any well-marketed “quick fixes” that promise to make everything better. It’s heartbreaking every time we encounter such patients.

Some of these sham treatments include:

No form of Shockwave Therapy Does heals Peyronie’s Disease

We were the country’s first private practice urologist to utilize low intensity shockwave (LiSW) therapy devices to treat erectile dysfunction, importing the technology direct from eastern Europe. After that, as the technology improved, we tested LiSW on Peyronie’s plaque. We discovered that it had no effect on plaque removal, using a comparative baseline duplex doppler imaginary of Peyronie’s fibrosis.

Based on our years of experience, we believe LiSW is an effective treatment for one of the four primary causes of erectile dysfunction. It is useless for treating Peyronie’s disease beyond the ability to improve erections in select cases and sometimes reduce pain.

No form of PRP injection heals Peyronie’s

Similarly, no aspect of PRP injections is successful treating Peyronie’s disease. Before publishing a valuable study on the success of shockwave therapy in treating aspects of Erectile Dysfunction2, renowned erectile dysfunction and Peyronie’s disease researcher Tom Lue, MD, spent two years attempting to leverage every variation of P-shots to heal the penis. It never worked. Importantly, he figured out why that pathway was fraught with failure: nocturnal erections.

Every man has 6-7 nocturnal erections every night during REM sleep. Within 48 hours of injection, 99% of implanted cells are gone. Because of the massive rush of penile blood flow during sleep, they never have a chance to heal anything within the penis.

There are no magic Peyronie’s pills or creams

Finally, there is no pill, supplement, or cream that can cure the disease. When each was properly tested against a placebo3, none showed any measurable improvement.

What’s next for ExoSurge® technology? Finish

We’ve been advised that getting FDA approval for our new gas injections / drug technology will cost more than $50 million (Is that amount insane or what?). We’ve already invested approximately $20 million over the last two decades in our pursuit of a cure for Peyronie’s Disease.

We’ve had to wait for key patents to be filed and issued before proceeding with any further steps. This impediment prevents us from sharing key data, publishing, or educating other urologists about the details of our breakthrough. All of these phases are occasionally distressing for our development team, as we see and hear about so many guys afflicted by this illness. Several members of our team have committed their entire careers and life savings in the development of this cure.

Our gas and intralesional medication injections for the treatment of Peyronie’s disease are not yet ready for sale; we aim to commence prospective trials for the technology in 2025 in collaboration with a new pharmaceutical partner.

Following prospective trials, we anticipate FDA approval of the device and intralesional drug injections, and then we’ll work with clinicians around the globe to deliver this revolutionary technology to patients seeking a permanent conservative Peyronie’s cure.

Similarly, we expect this technology will be fully reimbursed by health insurance.

[2] Pakpahan, et al:  Low-energy Shock Wave Therapy Ameliorates Erectile Dysfunction in a Pelvic Neurovascular Injuries Rat Model, World Journal of Stem Cells, Volume 13, 10, October 26, 2021.
[3] Oral therapy for Peyronie’s: does it work? Brittani Barret-Harlow, Run Wang, Vol. 5, No. 3, June 1, 2016, Translational Andrology and Urology

Free Initial Consultation

Do you want to know if ExoSurge is right for you? We provide a free initial case consultation over the phone to evaluate your current condition and determine if ExoSurge treatment is appropriate for you in the future. Most insurance plans (including Medicare) usually cover the costs of the extensive testing required to develop an accurate treatment plan for your Peyronie’s disease. However, there will be out-of-pocket expenses for care, which can be costly if you travel from out of state and must include travel costs, lodging, and meals.

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